What are Designerbodies™
Designerbodies™ are fully synthetic, small proteins engineered to bind specifically to selected epitopes on target proteins. Their deliberate design gives them unique and superior characteristics compared to naturally occurring antibodies derived from traditional in vivo or in vitro screening platforms.
Defined target epitope
Unlike conventional antibodies, where the target epitope is determined by natural selection and challenging to identify, Designerbodies™ have predefined epitope-paratope interactions. The ARCANE™ platform allows us to tailor the binding site to match the intended application.
Development
Designerbodies™ are rapidly developed without animals or cell-based systems, making them efficient, ethical, and eco-friendly. They can be mass-produced in microbial systems for high yields at low cost, and thanks to the ARCANE™ platform, they offer excellent thermal and room-temperature stability.
Tags and incorporated functionalities
Designerbodies™ are smaller than antibodies and lack an Fc-backbone by default but can be easily modified with functional tags for e.g. detection or linking to other proteins. They’re ideal for rapid in vitro and in vivo proof-of-concept studies on target inhibition.
Ease of development
Monoclonal antibody development can be difficult when targets are non-immunogenic or the antigen is hard to come by. Designerbodies™ bypass these challenges, making them ideal for targets with known structures but where the antigen is unavailable.
