FAQs
Find the answers here
Target protein
Q: Do I need to have a target sequence?
A: Yes, that is the minimum information we do require
Q: Do I need an experimentally resolved structure of my target?
A: No, if you don't have an experimental structure and there are none in the literature, we can generate it in silico. It can however be difficult if your target is particularly disordered.
Q: Who is responsible for the physical target protein when I want in vitro validation?
A: We ask the customer to send us the physical target protein to ensure no time delays.
Q: How much target protein do you need?
A: None if you only want DesignerbodyTM sequences. If you want them as validated proteins, still only very little (~100 μg).
Target binding site info
Q: Can you target a specific binding site?
A: Yes, we can design to specific target binding sites. However, certain sites are intrinsically difficult to generate binders to, due to amino acid properties.
Q: If I don't know what site to target, can you still tell me where my binders will bind?
A: Yes, we can even try to generate a series of binders targeting different sites on your target.
Q: How sure are you that you have predicted the right target binding site?
A: When a Designerbody™ binds, we are confident that the binding occurs on the predicted region of the target.
Designerbodies
TM
Q: What are Designerbodies™?
A: They are custom AI generated binders that are optimised to their given targets.
Q: How big are Designerbodies™?
A: They can be any size you want them to be, but we have had most success in sizes ranging from 10-15kDa.
Q: If I buy only the Designerbody™ sequences, how sure are you that something will bind?
A: Our success rates vary between different types of targets. For most targets, the success rate lies between ~5-50% (nM-pM binding). For other types of targets it can be <1%. Crucially, we leverage our experience to estimate the succes rate for the given target and designs before we commence on a design compaign. The risks and likelihood of success are communicated to our customers well beforehand.
